李先辉，男，1976年5月生，湖北当阳人，中共党员，华中科技大学药理学博士，教授，硕士研究生导师，湖南省芙蓉青年学者，湖南省青年骨干教师，吉首大学第三届“青年科技之星”，湖南省检验教育专业委员会专业委员，湘西自治州药学会副主任委员、常务理事，Neurochemistry International、Neurotoxicity Research、Pharmaceutical Biology等期刊特约审稿人。主持国家自然科学基金课题4项，教育厅重点项目1项，一般项目1项，主持国家民委等教改项目4项；获省级科技成果进步奖三等奖1项，校级教学成果二等奖2项，发表SCI论文20余篇，主编参编教材3部，专著1部。
联系方式：Email:lxhsurgeon@163.com; Tel: 18707439733
【研究领域】
1.神经退行性和代谢性疾病药物靶点的确定及药效学评价
2.民族药物网络药理学机制研究
【主持的主要科研项目】
1.国家自然科学基金地区基金项目.NO. 81260489.内质网应激PERK 信号通路
与阿尔茨海默病的关系及大蒜素的保护作用研究.2012-2014
2.国家自然科学基金地区基金项目.NO. 81460547.Cdk5介导的AMPKα2蛋白磷
酸化在糖尿病脑病中的作用机制研究.2014-2018
3.国家自然科学基金地区基金项目.NO. 81660598.海马Fndc5基因启动子区组蛋
白甲基化修饰在糖尿病脑损伤中的作用.2016-2020
4.国家自然科学基金地区基金项目.NO. 81860636LncRNA NONRATG022419调控
PRG-1的表达在糖尿病脑损伤中的作用及机制研究.2018-2022
5.湖南省教育厅重点项目.NO.14A117主持Cdk5介导的AMPK蛋白磷酸化在糖尿
病脑损伤中的作用机制研究.2014-2018
窗体顶端
【主要学术论文】
1.Yan Li , Qiong Xiang , Yu-Han Yao , Jing-Jing Li , Yan Wang , Xian-Hui Li （通讯）.Inactivated AMPK-α2 promotes the progression of diabetic brain damage by Cdk5 phosphorylation at Thr485 site.Biochimie. 2020 Jan;168:277-284
2.Qiong Xiang , Jing-Jing Li , Chun-Yan Li , Rong-Bo Tian ,Xian-Hui Li（通讯）Somatostatin Type 2 Receptor Antibody Enhances Mechanical Hyperalgesia in the Dorsal Root Ganglion Neurons after Sciatic Nerve-pinch Injury: Evidence of Behavioral Studies and Bax Protein Expression.CNS Neurol Disord Drug Targets. 2019;18(10):791-797.
3.Xiang Q, Xian-Hui Li（通讯）, Fang XX, Jia J, Ren J, Dong YC, Ou-Yang C.Alterations of synaptic plasticity in aged rats: Evidence of functional and morphological studies.Technol Health Care. 2018;26(2):271-278.
4.Xiang Q,Xian-Hui Li（通讯）, Yang B, Fang XX, Jia J, Ren J, Dong YC, Ou-Yang C, Wang GC.Allicin attenuates tunicamycin-induced cognitive deficits in rats via its synaptic plasticity regulatory activity.Iran J Basic Med Sci. 2017 Jun;20(6):676-682.
5.Zhu YF,Xian-Hui Li（通讯）, Yuan ZP, Li CY, Tian RB, Jia W, Xiao ZP.Allicin improves endoplasmic reticulum stress-related cognitive deficits via PERK/Nrf2 antioxidative signaling pathway.Eur J Pharmacol. 2015 Sep 5;762:239-46.
6.Xiang Q, Yu C, Zhu YF, Li CY, Tian RB,Xian-Hui Li（通讯）.Nuclear factor erythroid 2-related factor 2 antibody attenuates thermal hyperalgesia in the dorsal root ganglion: Neurochemical changes and behavioral studies after sciatic nerve-pinch injury.Injury. 2016 Aug;47(8):1647-54.
7.Xiang Q, Zhang J, Li CY, Wang Y, Zeng MJ, Cai ZX, Tian RB, Jia W,Xian-Hui Li（通讯）Insulin resistance-induced hyperglycemia decreased the activation of Akt/CREB in hippocampus neurons: Molecular evidence for mechanism of diabetes-induced cognitive dysfunction.Neuropeptides. 2015 Dec;54:9-15.
8.Xian-Hui Li, Xin X, Wang Y, Wu JZ, Jin ZD, Ma LN, Nie CJ, Xiao X, Hu Y, Jin MW. Pentamethylquercetin protects against diabetes-related cognitive deficits in diabetic Goto-Kakizaki rats.J Alzheimers Dis. 2013;34(3):755-67.
9.Xian-Hui Li, Li CY, Lu JM, Tian RB, Wei J.Allicin ameliorates cognitive deficits ageing-induced learning and memory deficits through enhancing of Nrf2 antioxidant signaling pathways.Neurosci Lett. 2012 Apr 11;514(1):46-50.
10.Xian-Hui Li, Li CY, Xiang ZG, Hu JJ, Lu JM, Tian RB, Jia W.Allicin ameliorates cardiac hypertrophy and fibrosis through enhancing of Nrf2 antioxidant signaling pathways.Cardiovasc Drugs Ther. 2012 Dec;26(6):457-65.
