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张永昌导师简介

基本信息

张永昌,男,1985年6月生,医学博士,副主任医师,硕士生导师,湖南省肿瘤医院肺胃肠内科副主任、湖南省呼吸肿瘤临床医学研究中心副主任。

人才荣誉及学术任职

国家优青,湖南省科技创新领军人才,第十一届湖南省青年科学家奖;中华医学会青年科技奖,湖南省青年五四奖章,湖南省委组织部“湖湘青年英才”,湖南省人才托举工程“年轻优秀科技人才”,湖南省“225”人才工程优秀科技人才,长沙市第五届“十大杰出青年”,CSCO Young委员/PICOS Young主任委员,湖南省医学会肿瘤内科专委会青委会委员,中国抗癌协会肿瘤呼吸病学专委会委员,中国抗癌协会肿瘤精准治疗专委会委员

研究方向

(1)早期肺癌精准诊断及治疗后复发监测;围绕早期肺癌的临床诊断,开发出基于液体活检及影像组学的高灵敏度及特异性的诊疗手段并开展临床队列验证;(2)肺癌靶向及免疫治疗耐药机制及干预策略研究;围绕肺癌靶向及免疫治疗耐药的基本原理,探讨其深层次的分子机制的转化研究并制定耐药后临床解决方案;(3)肺癌定向器官转移的分子机制及临床诊治;围绕肺癌脑转移等特定器官转移的发生机制、分子特征等相关领域开展基础及临床转化研究,解决诊疗难题。

联系方式:zhangyongchang@csu.edu.cn

近3年代表性学术成果

序号

论文(专著)

名称/刊名/作者

年卷页码(xx年xx卷xx页)

发表(出版)时间(年月日)

他引总次数

检索数据库

1

Detection of Nonreciprocal/Reciprocal ALK Translocation as Poor Predictive Marker in Patients With First-Line Crizotinib-Treated ALK-Rearranged NSCLC. Journal of thoracic oncology.Zhang, Y., Zeng, L., Zhou, C., Li, Y., Wu, L., Xia, C., Jiang, W., Hu, Y., Liao, D., Xiao, L., Liu, L., Yang, H., Xiong, Y., Guan, R., Lizaso, A., Mansfield, A. S., & Yang, N. (2020).共同第一作者排第一(1/5), PMID: 32112982

Journal of thoracic oncology: 15(6), 1027–1036.

2020 Jun.

Journal Impact Factor (2021): 20.121

35

Web of Science

2

Efficacy and Safety of Apatinib Plus Vinorelbine in Patients With Wild-Type Advanced Non-Small Cell Lung Cancer After Second-Line Treatment Failure: A Nonrandomized Clinical Trial. JAMA network open. Zhang, X., Xiong, Y., Xia, Q., Wu, F., Liu, L., Zhou, Y., Zeng, L., Zhou, C., Xia, C., Jiang, W., Liao, D., Xiao, L., Liu, L., Yang, H., Guan, R., Li, K., Wang, J., Lei, G.,Zhang, Y., & Yang, N. (2020).通讯作者(1/1), PMID: 32191330

JAMA network open, 3(3), e201226.

2020 Dec.

Journal Impact Factor (2021): 13.353

12

Web of Science

3

Clinical impact of uncommon epidermal growth factor receptor exon 19 insertion-deletion variants on epidermal growth factor receptor-tyrosine kinase inhibitor efficacy in non-small-cell lung cancer. European journal of cancer. Peng, X., Long, X., Liu, L., Zeng, L., Yang, H., Jiang, W., Liao, D., Li, K., Wang, J., Lizaso, A., Mao, X., Xu, Q., Mansfield, A. S., Yang, N., &Zhang, Y. (2020).通讯作者(1/2), PMID: 33171317

European journal of cancer (Oxford, England : 1990), 141, 199–208.

2019 Apr.

Journal Impact Factor (2021): 10.022

8

Web of Science

4

Association Between Sex and Immune-Related Adverse Events During Immune Checkpoint Inhibitor Therapy. Journal of the National Cancer Institute, Jing, Y.,Zhang, Y., Wang, J., Li, K., Chen, X., Heng, J., Gao, Q., Ye, Y., Zhang, Z., Liu, Y., Lou, Y., Lin, S. H., Diao, L., Liu, H., Chen, X., Mills, G. B., & Han, L. (2021).共同第一作者排第二(2/4), PMID: 33705549

Journal of the National Cancer Institute, 113(10), 1396–1404.

2021 Oct 1.

Journal Impact Factor (2021): 11.816

9

Web of Science

5

Profiling of immune features to predict immunotherapy efficacy. Innovation (New York, N.Y.). Ye, Y.,Zhang, Y., Yang, N., Gao, Q., Ding, X., Kuang, X., Bao, R., Zhang, Z., Sun, C., Zhou, B., Wang, L., Hu, Q., Lin, C., Gao, J., Lou, Y., Lin, S. H., Diao, L., Liu, H., Chen, X., Mills, G. B., … Han, L. (2021).共同第一作者排第二(2/4), PMID: 34977836

Innovation (New York, N.Y.), 3(1), 100194.

2021 Dec 2, Journal Impact Factor (2021): 28.506

7

Web of Science

6

Disease progression patterns and molecular resistance mechanisms to crizotinib of lung adenocarcinoma harboring ROS1 rearrangements.Zhang, Y., Huang, Z., Zeng, L., Zhang, X., Li, Y., Xu, Q., Yang, H., Lizaso, A., Xu, C., Liu, J., Wang, W., Song, Z., Ou, S. I., & Yang, N. (2022).共同第一作者排第1(1/3), 共同通讯排第二(2/2), PMID: 35361870

NPJ precision oncology, 6(1), 20.

2022 Mar 31, Journal Impact Factor (2021): 10.092

3

Web of Science

7

Clinical and molecular feature-based nomogram model for predicting benefit from bevacizumab combined with first-generation EGFR-tyrosine kinase inhibitor (TKI) in EGFR-mutant advanced NSCLC. Zhang, Y., Zhang, X., Zhang, R., Xu, Q., Yang, H., Lizaso, A., Xu, C., Liu, J., Wang, W., Ou, S. I., Zhang, J., Song, Z., & Yang, N. (2021). 共同第一作者排第1(1/3), 共同通讯排第二(2/2), PMID: 34663309

BMC medicine, 19(1):245

2021 Oct 19, Journal Impact Factor (2021): 11.150

5

Web of Science

8

Clinical and molecular factors that impact the efficacy of first-line crizotinib in ROS1-rearranged non-small-cell lung cancer: a large multicenter retrospective study.Zhang, Y., Zhang, X., Zhang, R., Xu, Q., Yang, H., Lizaso, A., Xu, C., Liu, J., Wang, W., Ou, S. I., Zhang, J., Song, Z., & Yang, N. (2021).共同第一作者排第1(1/3), 共同通讯排第二(2/2), PMID: 34511132

BMC medicine, 19(1), 206.

2021 Sep 13, Journal Impact Factor (2021): 11.150

5

Web of Science

 

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